American Journal of Industrial Medicine. Vol. 57, Iss. 2, February 2014
Work-related spirometric restriction in flavoring manufacturing workers
Background Flavoring-exposed workers are at risk for occupational lung disease.
Methods We examined serial spirometries from corporate medical surveillance of flavoring production workers to assess abnormality compared to the U.S. population; mean decline in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC); and excessive declines in FEV1.
Results Of 106 workers, 30 had spirometric restriction, 3 had obstruction, 1 had both, and 13 (of 70, 19%) had excessive declines in FEV1. The adjusted prevalence of restriction was 3.7 times expected. Employees with higher potential for flavorings exposure had 3.0 times and 2.4 times greater average annual declines in FEV1 and FVC respectively, and had 5.8 times higher odds of having excessive FEV1 declines than employees with lower potential for exposure.
Conclusion Exposure-related spirometric abnormalities consistent with a restrictive process evolved during employment, suggesting that exposures in flavoring production are associated with a range of pathophysiology.
Keywordsdiacetyl, excessive decline, flavorings, hydrogen sulfide, spirometric restriction, spirometry
Articoli correlati che potrebbero interessarti
Respiratory function in power plant workers exposed to nitrogen dioxide
Occupational Medicine (Oxford Journals). Vol. 64, Iss. 8, December 2014
Longitudinal decline in pulmonary diffusing capacity among nitrate fertilizer workers
Occupational Medicine (Oxford Journals). Vol. 64, Iss. 3, April 2014
Pulmonary responses in current smokers and ex-smokers following a two hour exposure at rest to clean air and fine ambient air particles
Particle and Fibre Toxicology. Vol. 10, Iss. 58, November 2013