Rassegna bibliografica

Journal of Occupational and Environmetal Medicine. Vol. 56, Iss. 3, March 2014

Urinary S-phenylmercapturic Acid as a Key Biomarker for Measuring Occupational Exposure to Low Concentrations of Benzene in Chinese Workers: A Pilot Study


Objective: This study analyzed the level of urinary S-phenylmercapturic acid (U-SPMA) for low benzene exposure in a group of Chinese shoe-making workers.

Methods: Urinary samples from 55 workers exposed to benzene at levels lower than 10 parts per million (ppm) were collected at postshift. U-SPMA level was determined using high-performance liquid chromatography/mass spectrography (HPLC/MS) method.

Results: Good linearity of U-SPMA was observed within the range from 10 to 320 μg/L (r = 0.9994). Concentration of airborne benzene ranged from 0.71 to 32.17 mg/m3, and three segments were divided with different levels of exposure (≤6.0, 6.0 to 10.0, 10 to 32.5 mg/m3), the median U-SPMA concentrations were 49.55, 102.15, and 335.69 μg/g Cr, respectively.

Conclusion: A good linear correlation was found between U-SPMA levels and airborne benzene concentrations. The selected method could be applied for detecting other working conditions in China.


Benzene, Biomarker, exposure, shoe-making workers, Urinary S-phenylmercapturic Acid

Articoli correlati che potrebbero interessarti

Whole-body vibration and the risk of low back pain and sciatica: a systematic review and meta-analysis

Vol. 88, Iss. 4, May 2015

Characterizing Adoption of Precautionary Risk Management Guidance for Nanomaterials, an Emerging Occupational Hazard

Journal of Occupational and Environmental Hygiene. Vol. 12, Iss. 1, January 2015

Occupational kneeling and squatting: development and validation of an assessment method combining measurements and diaries

Vol. 88, Iss. 2, February 2015