Rassegna bibliografica

Journal of Occupational and Environmetal Medicine. Vol. 56, Iss. 3, March 2014

Occupational Exposure to Cyclophosphamide in Nurses at a Single Center


Objective: To evaluate biological and environmental exposure to cyclophosphamide in nurses at a single institution.

Methods: Biological exposure to cyclophosphamide in nurses administering cyclophosphamide compared with two control groups: nononcology nurses not administering cyclophosphamide and community members without recent hospital exposure. Environmental exposure to chemotherapy was measured using surface wipes taken from oncology and nononcology areas in the hospital.

Results: More than one third of all nurses and no community controls tested positive for urinary cyclophosphamide. Oncology and nurse controls tested positive in equal numbers. Surface wipes were positive only in the oncology ward.

Conclusion: We have demonstrated elevated levels of cyclophosphamide in one third of all nurses and cyclophosphamide contamination of surfaces within the oncology patient environment. This suggests that environmental contamination plays a major role in biological exposure to cyclophosphamide.


Cyclophosphamide exposure, hospital, Nurses

Articoli correlati che potrebbero interessarti

Adherence to Precautionary Guidelines for Compounding Antineoplastic Drugs: A Survey of Nurses and Pharmacy Practitioners

Journal of Occupational and Environmental Hygiene. Vol. 12, Iss. 9, September 2015

Multicenter Study of Environmental Contamination with Antineoplastic Drugs in 36 Canadian Hospitals: A 2013 Follow-up Study

Journal of Occupational and Environmental Hygiene. Vol. 12, Iss. 2, February 2015

Shift work and burnout among health care workers

Occupational Medicine (Oxford Journals). Vol. 64, Iss. 4, June 2014