Biological Effects of Emissions From Resistance Spot Welding of Zinc-Coated Material After Controlled Exposure of Healthy Human Subjects
Objective: Do emissions from a resistance spot welding process of zinc-coated materials induce systemic inflammation in healthy subjects after exposure for 6 hours?
Methods: Twelve healthy male subjects were exposed once for 6 hours either to filtered ambient air or to welding fume from resistance spot welding of zinc-coated material (mass concentration approximately 100 μg m−3). Biological effects were measured before, after, and 24 hours after exposure.
Results: At the concentrations used in this study, however, the suspected properties of ultrafine particles did not lead to systemic inflammation as reflected by high-sensitivity C-reactive protein or other endpoint parameters under consideration.
Conclusions: Ultrafine particles from a resistance spot welding process of zinc-covered materials with a number concentration of about 106 cm−3 and a mass concentration of about 100 μg m−3 did not induce systemic inflammation.